Children wearing traditional clothing and holding pets pose for a photograph expecting money in return in Cuzco, Peru, on Wednesday, Feb. 4, 2008.

Although pet parents are well aware of poisons lurking around their home, many don’t realize that some of the biggest culprits are sitting right on their own nightstands.

In 2007, the ASPCA Animal Poison Control Center received 89,000 calls related to pets ingesting over-the-counter and prescription medications. To help you prevent an accident from happening, our experts have created a list of the top 10 human medications that most often poison our furry friends.

If you suspect your pet has ingested any of the following items, please call your veterinarian. And remember to keep all medications tucked away in bathroom cabinets—and far from curious cats and dogs.

NSAIDs
NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen or naproxen are the most common cause of pet poisoning in small animals, and can cause serious problems even in minimal doses. Pets are extremely sensitive to their effects, and may experience stomach and intestinal ulcers and—in the case of cats—kidney damage.

Antidepressants
Antidepressants can cause vomiting and lethargy and certain types can lead to serotonin syndrome—a condition marked by agitation, elevated body temperature, heart rate and blood pressure, disorientation, vocalization, tremors and seizures.

Acetaminophen
Cats are especially sensitive to acetaminophen, which can damage red blood cells and interfere with their ability to transport oxygen. In dogs, it can cause liver damage and, at higher doses, red blood cell damage.

Methylphenidate (for ADHD)
Medications used to treat ADHD (Attention Deficit Hyperactivity Disorder) in people act as stimulants in pets and can dangerously elevate heart rates, blood pressure and body temperature, as well as
cause seizures.

Fluorouracil
Fluorouracil—an anti-cancer drug—is used topically to treat minor skin cancers and solar keratitis in humans. It has proven to be rapidly fatal to dogs, causing severe vomiting, seizures and cardiac arrest even in those who’ve chewed on discarded cotton swabs used to apply the medication.

Isoniazid
Often the first line of defense against tuberculosis, isoniazid is particularly toxic for dogs because they don’t metabolize it as well as other species. It can cause a rapid onset of severe seizures that may ultimately result in death.

Pseudoephedrine
Pseudoephedrine is a popular decongestant in many cold and sinus products, and acts like a stimulant if accidentally ingested by pets. In cats and dogs, it causes elevated heart rates, blood pressure and body temperature as well as seizures.

Anti-diabetics
Many oral diabetes treatments—including glipizide and glyburide—can cause a major drop in blood sugar levels of affected pets. Clinical signs of ingestion include disorientation, lack of coordination and seizures.

Vitamin D derivatives
Even small exposures to Vitamin D analogues like calcipotriene and calcitriol can cause life-threatening spikes in blood calcium levels in pets. Clinical signs of exposure—including vomiting, loss of appetite, increased urination and thirst due to kidney failure—often don’t occur for more than 24 hours after ingestion.

Baclofen
Baclofen is a muscle relaxant that can impair the central nervous systems of cats and dogs. Some symptoms of ingestion include significant depression, disorientation, vocalization, seizures and coma, which can lead to death.